Strain-Encoding (SENC) Imaging

Strain Encoding (SENC) in Magnetic Resonance Imaging is a technique developed by Nael Osman’s group at Johns Hopkins University for imaging the strain of deforming tissue using MRI. Relevant Papers Garot J, Bluemke DA, Osman NF, Rochitte CE, Zerhouni EA, Prince JL and Lima JA. Transmural contractile reserve after reperfused myocardial infarction in dogs. J […] Read More

Harmonic Phase (HARP) Imaging

The HARmonic Phase (HARP) algorithm[1] is a medical image analysis technique capable of extracting and processing motion information from tagged magnetic resonance image (MRI) sequences. Initially developed by N. F. Osman and J. L. Prince at the Image Analysis and Communications Laboratory at Johns Hopkins University. The method uses spectral peaks in the Fourier domain […] Read More

Chemotherapy / Cardiotoxicity

New advances in chemotherapies have offered significant improvements in cancer survival, but can often present negative side effects to the heart. Researchers are able to use Myocardial Solutions’ products like HARP® to measure subtle changes in heart function to assess the cardiotoxicity of certain chemotherapies. In addition, using our VIRTUE platform, researchers can analyze tissue […] Read More

Coronary Artery Disease (CAD)

Coronary Artery Disease is the disease that affects the coronary arteries and typically in a chronic or acute ischemic event.  The resulting heart problems (such as angina and myocardial infarction) are recognized as Coronary Heart Diseases (CHD).  CAD and CHD are the most common problems in adults and the leading cause of death in the […] Read More

Myocardial Infarction

Myocardial infarction (from Latin: Infarctus myocardii, MI) or acute myocardial infarction (AMI) is the medical term for an event commonly known as a heart attack. An MI occurs when blood stops flowing properly to a part of the heart, and the heart muscle is injured because it is not receiving enough oxygen. Usually this is […] Read More


Cardiomyopathy is the measurable deterioration of the function of the myocardium which typically leads to heart failure, irregular heart beat, or sudden cardiac death. Cardiomyopathies, however, are not attributed directly to coronary heart disease. There are a number of different contributing factors, although in specific patients, it may be difficult to know the exact cause.  The important point […] Read More

Hypertrophic Cardiomyopathy

Hypertrophic Cardiomyopathy (HCM) is the most common cardiomyopathy.  It results in an unhealthy thickening of the heart wall, which leads, in many cases, to obstructing the blood flow through the aortic valve, or compromises the function of the aortic valve. Function of the LV wall changes in different regions as the disease progresses, and one […] Read More

Duchenne Disease

Duchenne muscular dystrophy (DMD) is a form of muscular dystrophy that occurs primarily in young boys and impacts muscles throughout the body.  One very common symptom includes cardiomyopathy, and Myocardial Solutions’ products are capable of analyzing the progression of disease as well as the impact of possible therapies. Measuring myocardial strain using products like HARP® can detect […] Read More


Myocardial contractility represents the intrinsic ability of the heart muscle (myocardium) to contract and contribute to the circulation of the blood.  Strain measurements correlate with the healthiness of the myocardium and its ability to contract.  Accurate measurement of strain, therefore, indicates myocardial contractility and overall function of the heart. Myocardial Solutions’ software and technology has led the […] Read More


Diastole is the period of time when the heart refills with blood after systole (contraction). Ventricular diastole is the period during which the ventricles are relaxing, while atrial diastole is the period during which the atria are relaxing. The term diastole originates from the Greek word διαστολη, meaning dilation. Strain quantification through HARP® or SENC™ […] Read More